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KMID : 0369319920120020178
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Allergy
1992 Volume.12 No. 2 p.178 ~ p.185
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Study on the Generation Frequency of Antigen Specific T-cell Clones in Asthma Patients Sensitized with House Dust Mite Dematophagoides pteronyssinus
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차미경
이상무/김현태/어수택/정연태/김용훈/ㅂ가춘식
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Abstract
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Allergic bronchial asthma is a typical disease of IgE mediated type I hypersensitivity. The role of T cell mediated cellular immune reactio9n has received more attention recently, because antigen specific T cell clones play the important roles in
requlation of IgE synthesis and lymphokine generation.
To evaluate the presence of T cell clone in peripheral blood(PB), responsive to house dust mites, in allergic patients, we measured the number of Dermatophagoides pteronysisnus (DP) antigen-specific T cell clone using limiting dilution method in
normal
subjects, the patients with non-atopic bronchial asthma and atopic bronchial asthma.
@ES The results were as follows:
@EN 1) The number DP antigen-specific T cell clone was higher in PB of allergic patients than control group (76.6% vs 37.5%).
2) Correlation of the number in DP antigen specific T cell clone in PB with serum IgE, specific IgE, and wheal size of skin test were not significant.
3) The number of T cell clone in the atopic patients with immunotherapy was less than atopic patients without immunotherapy, but was not significant (0.024±0.026% vs, 0.058±0.102%, p>0.05).
In conclusion, DP antigen specific T cell clone is more frequently present in peripheral blood of the patients with bronchial asthma sensitized to DP antigen and the number of T cell clone show a decreasing tendency after immunotherapy.
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